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Combined serotonergic agonism and mu opioid receptor activity creates an adverse drug reaction risk profile not addressable by harm reduction principles targeting either mechanism individually. Go dira dilo tse di go kgatlhegelang, go ikopanya le batho ba bangwe, le go dira dilo tse di dira gore o ikutlwe sentle, di dira gore o itselele mo botshelong. The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.